Summary - Health and Fitness

The right smile could do more than help you look good the next time your picture is taken –

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

it might help you socially and professionally as well.

A recent study, published in the Jou

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nal of Dentistry, reported that smile-makeover patients feel more “at ease in social setting

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s, having the confidence to express opinions, being more sociable and greeting people sponta

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

eously.” In addition, to a significant number of people reported improved work situations,

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

especially where it involves face-to-face interaction, the study said.

“Smile makeover” pat

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ents in the study received some form of cosmetic dentistry to improve the looks of their smi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

les.

“Based on scores of patient testimonials, there is a very good chance that after havin

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

cosmetic dentistry you will acquire self-confidence and self-esteem at a level you have nev

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

er had before,” says Dr. William Dickerson, founder of LVI, considered by many dentists the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eading postgraduate dental training center in the world. “Patients tell us that looking and

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

feeling more attractive has had a highly positive impact on both their personal and profess

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

onal lives.”

Dickerson says that due to technological advancements and training in the fiel

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d, a smile-makeover by a trained cosmetic dentist can now be completed in two or three offic

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

visits.

Cosmetic dentistry includes many procedures from smile whitening to straightening,

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

repairing or replacing chipped, discolored or worn teeth – even eliminating silver fillings

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Dickerson says the most worst smiles can be whitened, straightened and improved without the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

need for unsightly, uncomfortable and time-consuming metal braces.

Experts recommend that

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eople considering smile-makeovers check the credentials of their cosmetic dentists. For ins

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tance, LVI trains dentists from around the world on the latest cosmetic dentistry techniques

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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