Summary - Health and Fitness

Rejuvenation refers to procedures used for reversing the aging process and regaining youthfulness. When people get older their health, strength, intell

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

igence and attractiveness diminishes. History of all societies is full of people have searched for ways to regain the charm of youth. The most famous i

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Alexander the Great who searched in the east for such an elixir. However it is ironical that Alexander died very young. In the future rejuvenation may

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

become reality through research on stem cells, biochemical repair or with nanotechnology.

History of Rejuvenation

Many stories and myths tell us of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

he quest for rejuvenation. In olden days it was believed that magic or supernatural powers could bring back youth. In the16th century many expeditions

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ere undertaken around the Caribbean islands and into Florida to find the “Fountain of Youth” but the fountain was never discovered. There were some pre

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

valent beliefs that certain potions or chemicals may restore youth.

The scientific method for rejuvenation started when quest for rejuvenation reached

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

its height with alchemy. All over Europe the alchemists were looking for mythical substances (Philosopher?s stone) which could turn anything into gold

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nd also restore youth. Although the goal was not achieved, alchemy laid the foundation for scientific methods and also to the medical advances of today

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

.

Modern Developments on Rejuvenation

As per modern science, there are no natural laws to prevent successful rejuvenation. Aging is the cumulative ef

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ect of damage to cells, tissues and organs. If damage can be repaired the result will be rejuvenation.

Many experiments have been done for rejuvenatio

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

but they have obtained the increase in life span. There are eight types of hormones which are the causes for aging factors:

Human growth hormone

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

> Sexual hormone e.g., testosterone or estrogen hormone
Erithropoietin (EPO)
Insulin
DHEA
Thyroid hormones
Melatonin
Pr

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

gnenolone.

These hormones are important in cell and tissue repair. With age these hormones reduce in number and effectiveness. However in theory the h

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rmones can be replaced thus the body should not age. Research is still going on to study the effect of these hormones.

Facial rejuvenation is a set of

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cosmetic procedures used to increase or restore the appearance of a younger age to the individual?s face by cosmetic surgery. The surgical procedures

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ries to restore facial geometry and appearance of skin using techniques/procedures like brow lift, elimination of eye bags, eyelids lift, facial saggin

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

and chin lift and restoration of facial hairline.

The present option available for rejuvenation involves cosmetic changes to the individual to create

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the appearance of youth. Cosmetic surgery changes the individual?s appearance thus elevating his/her happiness level and may have positive side effect

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

. Cosmetic surgery of body involves removal of wrinkles on face, removal of extra fat (liposuction) and reshaping or augmentation of various body parts

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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