Summary - Relationships

How clich? and hurtful to hear the phrase “I love you, but I’m not in love with you”. It’s a crock. It’s a noble attempt for the speaker to feel good about ending a relationship. They say this to ease their own p

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ain and to make themselves feel like they bowed out gracefully. It’s bull. There’s usually something else going on and the recipient usually feels a loss and at fault. You are either loved or you’re not. That’s

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he bottom line. So which is it? The recipient struggles to find out and enters the darkest of hours searching their heart and soul trying to find out.

It hurts to hear similar phrases. The recipient feels that t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ere may be a chance if they are still loved in any fashion. They may also have found guilt in themselves for many different reasons. They will rationalize their own behavior and lay the entire blame on themselves.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

It’s a natural instinct to do so, but it is so unfair. The recipient will go through many phases of emotions; hurt, remorse, anger, and the list goes on and on. This dark moment can disrupt their lives and cause

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

o much harm. They will go through a period where they can’t eat, sleep, and function properly in their daily activities. Why? They are still in love.

The emotional roller coaster is relentless. The best advice

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

or this person who is hurting is to share their thoughts and feelings with family, friends and trusted co-workers. Don’t keep it bottled up inside. Keeping it to oneself with only intensify the lasting effects. I

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

’s difficult to be strong in such a situation, and the person hurting can not do it alone. Support is the best way to easy the pain, even if the person feels like a failure or embarrassed over the particulars of th

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

failing relationship.

The most important thing is to go through the emotions. Let it all hang out, so to speak. Whether in private or among trusted individuals, just let it out. It’s amazing what kind of relief

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

you can have by sharing your thoughts and true emotions. Break down and cry. Shout if you want. It doesn’t matter. Just get it out. It’s part of the healing stage.

Denial is a natural feeling also, but there w

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ll come a time when true reality kicks in. It’s a state of mind. How you vent that denial or accept it will determine your next course. It’s also a part of the healing stage or acceptance. There is no right way

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r wrong way to do this, but you will come to the point where anger kicks in.

Don’t let thoughts of revenge rule your state of mind. It’s so easy to find ways to seek revenge. It’s a natural defense, but it’s not

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

orth it. Remember, you are much better than that. Don’t allow yourself to stoop to a level that you will later regret. Try your best to be yourself. Don’t do anything out of the norm, whether you have accepted t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e end of the relationship or have decided to sit back and see what happens. Be an adult and one day you will be proud of the way you handled you the situation.

The one thing you can do is reassure yourself that yo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

did nothing wrong. Your partner had the obligation of communication. If something was wrong, they should have spoken up. They would have done this if they truly ‘loved you’. That’s not much consolation in your

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

time of grief, but it’s the truth.

If you and your partner can work through this dark moment in your relationship, then that’s a victory that will forever create a bond that will be so difficult to break. It will

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rove to build a stronger relationship than you ever have imagined. Sometimes it takes a traumatic moment in our lives to acquire a solid foundation. We make think we have it but the test of time and life’s trials

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ill prove whether or not we can build that sort of foundation.

It’s going to hurt your heart and soul, but if it was meant to be, it will. Have faith. There is always a purpose in life and we may never understand

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

it at that the time, but someday we will.

Patience is the worst part. It’s a virtue that will pay off in the end, no matter the outcome of your ordeal, whether you believe it or not.

The grass is always greener o

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the other side, and it’s natural to want to purchase a gallon of ‘Round-Up’ and kill it. Have patience. Crab grass can grow everywhere but it’s the ‘weed and feed’ that builds that everlasting strong relationship

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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