Summary - Relationships

Why do women date jerks? The answer to this question is actually a lot more complicated than one might think. We are going to have to blame Mother Nature for this seemingly illogi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cal behavior.

In his book “Sperm Wars”, Robin Baker says that humans are biologically driven to ensure their genetic survival. Males want to ensure that their genes inseminate; fe

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ales want to ensure that they are impregnated by the best possible genes available.

If you ask women what type of guy they’re looking for, they’ll usually say they want someone hon

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

est, faithful, ambitious, intelligent, etc. However, this is not what they are usually attracted to. Women are attracted to a man’s personality above all else, and will use this a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

a measuring stick of his genetic superiority or lack thereof.

A dominant male personality (jerks fall into this category) is generally preferred over a male that is submissive (ot

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

herwise known as a “wimp”). The former is sending an unconscious message that he has great genes and is not afraid of losing the woman by misbehaving. The latter is sending a mess

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ge that he doesn’t think his genes are good enough, so he’ll put up with just about anything.

We also need to consider the “Triune Brain Theory”. In 1973, Dr. Paul MacLean, senior

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

research scientist at the National Institute of Mental Health, proposed that the brain is made up of three subdivisions corresponding to three evolutionary eras.

The first, most p

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

imal part of the brain is the reptilian. It is responsible for mating and territorial behavior, pecking order, defense, aggression and the emotions of anger and fear.

The second p

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

art of the brain to develop was the limbic brain. Love, sadness, jealousy and hope originate here. It controls heartbeat, temperature, blood pressure and the flow of neurotransmit

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ers, all of which are affected by the presence of someone we’re attracted to. Sexual stimuli passes directly to it. It is impulsive and instinctual. It is not receptive to reason an

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

d analysis.

The newest part of our brain, the neo-cortex, permits higher functions of logic, thought, language, planning, reasoning and critical judgement.

In “The Emotional Brai

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

”, Joseph LeDoux points out that the first two, older brains have a greater influence on the neo-cortex than vice-versa, “making it possible for emotional arousal to dominate and co

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ntrol thinking. Although thoughts can easily trigger emotions we are not very effective at turning emotions off.”

This means that the lower limbic system, which rules emotions, ca

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hijack the higher mental functions when it needs to. It says, “You’ve found The One”. The neo-cortex responds with, “Yes, but he seems to drink too much, I’ve caught him lying an

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

d he doesn’t have a job.” The limbic says, “I can live with that. He’s so handsome and it feels so wonderful when I’m with him.”

You can see how even though a woman may say she w

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nts a nice guy, that is not necessarily who she is attracted to. A great example of this is food. Do we make our choices based on what’s good for us or on what tastes good? This

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

is what is happening when a woman chooses someone that makes her feel good, but is not good for her.

The solution? Men need to find a happy medium between being a bad guy and bein

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

a wimp. They can be strong and take charge but they also need to know when to be more sensitive and yielding. Women? They need to date a few jerks to see that the emotional high

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

they get from being with them isn’t worth the pain and sadness that ultimately ensues. Only then will they be able to turn the tables on the limbic brain and make a logical choice

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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