Summary - Relationships

Lately I’ve had a run of clients having a very hard time getting over the end of a relationship, so let me share some secrets with you about how to heal.

I have a client called Dorothy who’s struggling to let go

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

of a relationship with a guy who she’d initially thought was perfect for her. When we first started working together Dorothy was really angry and frustrated that, yet again, she was going to have to re-build her l

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ove life. The one good thing about those feelings was that they removed any temptation to get straight back into dating.

The first step for any client I work with in this situation is to have them feel the

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ir feelings which is an essential part of the healing process.

Some people really struggle with feeling certain feelings. Some of us are easier with anger, others with grief. Dorothy was more than comfortable wit

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

being angry but was very reluctant to admit that her anger was masking her feelings of hurt and loneliness. Those feelings made her feel vulnerable in a way she resisted furiously. I encouraged her to explore all

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

of her feelings by writing a ‘grief letter’ to her ex.

The Grief Letter

To write your letter take the time to explore what you are going to miss and what you aren’t going to miss.

- What are you angry

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

about?
- What are you sad about?
- What do you fear this break up means?
- What was your part in the break up?
- What are you always going to love or appreciate about your ex?

This is

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

referred to as a ladder of emotion and it’s great to write your letter in the above order. Feel free to use those questions as headers. That said if you need to keep coming back to anger then please do and then w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rk your way back up the ladder again.

It’s important that you realise that you are never going to send this letter, this way you can explore being totally unreasonable and maybe even, what would previously

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

have been, unbearably open about just how hurt you feel.

Explore these questions in such a way that you can feel all the things you suspect may be true even if you’d rather they weren’t. Write the letter as if y

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ou were writing it to someone who really cares about how you feel.

It’s really important that you take time to do this. Every time you leave a relationship there is a danger that you will suppress your emotions d

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ue to the pain and disappointment. That suppression continues after the breakup and makes you less attractive and can begin to limit your ability to love.

If you go through this phase of feeling your feelings pro

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

erly then you’ll be able to reconnect with at least some of the love you felt for this person you’ve parted from. Not in a way that eats at you but in a way that nourishes your sense of having a life worth loving.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

If you’ve loved deeply once, then you can do it again. It takes work to keep your heart healthy and open but it’s very valuable work.

This is the first step in a process that can take anywhere from days t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

o months and it’s a good solid first step. When Dorothy first began to be honest about how sad and lonely she felt she got scared about how overwhelming it felt. As if somehow she could become lost in the feelings

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

or she’d never feel good again. This process requires you to acknowledge that your feelings are not something to be afraid of. If you’re feeling sad you are only sad. It doesn’t necessarily mean there’s something

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

wrong with your life that must be fixed. Sometimes the best thing you can do for yourself is to just acknowledge that you do feel sad.

The end of a relationship is often the death of something you found to be bea

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

utiful for a while. That said, no matter how big your grief is, you’re going to get through it. You are far bigger than your worst feeling.

Two months on Dorothy has learned a lot about her self and one of her un

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

expected breakthroughs is that being alone at home no longer makes her feel like there’s something wrong with her. Suddenly being alone isn’t so scary and from this place she’s in a much better position to think a

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

bout who she’d actually like to make a part of her life.

Feeling your feelings is the quickest route to healing and the only way out is through. Just remember that even your darkest minute is only 60 seconds long

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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