Summary - Relationships

You may remember all the good times you had, the special way you greeted each other. You close your eyes and you can almost feel him next to you. Former

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

spouses or love partners can become larger than life. We tend to remember only the good. We put our former partner on a pedestal. No mere mortal could

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ever live up to those standards so we hold on to the past. You may dream that one day you will open the door and your former lover will be standing ther

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pledging his undying love to you. Or your spouse may have died and you struggle with a feeling that you would betray your spouse if you were to fall in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

love. We may have made a promise consciously or unconsciously long ago to another that keeps us from letting go.

Letting go is acknowledging the loss

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

f many dreams including: growing old together or the loss of not having children or grandchildren together. Letting go requires us to face reality, to s

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ee both our ex and ourselves as we really are, our flaws, our imperfections, and our humanity. For many this is just too painful. Rebound relationship

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

can be particularly hard to let go of. You met at a time when you were particularly vulnerable and somehow gave much of the job of your healing to your

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

partner. When the rebound relationship fails you feel devastated.

We often give the responsibility for our healing to a former spouse, our rebound rel

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

tionship or another love partner. We may not be able to let go because it’s scary. Fear of the unknown. Fear of being lonely. Fear of not being able

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

to take care of ourselves. Fear of never being loved again. Fear keeps us from moving on. Letting go requires facing these fears and taking charge of

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

your own life. We also stay connected with our ex through anger, yelling, and blame. We keep going back to court. We deplete our energy by trying to ge

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

even and then instead of feeling better we feel even worse. Or we are angry at God that death cheated us out of the only one that has ever loved us.

I

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t is easier to let go if you work on other areas of your life. Do you have a good group of friends? Is your career going well? Do you have interests a

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

d hobbies that you enjoy? Do you take good care of yourself? Or do you invest your energy in the dead relationship instead of in yourself and in your f

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

uture? Accept that you and your former lover partner will not get back together.

Have faith in yourself. You possess everything you need for your own

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ealing. If you feel stuck or that you will never get over this relationship then talk with friends or see a therapist. Discover what is keeping you

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

from letting go, moving on and being able to create the love and relationships you want. It is possible to let go and move on and life can be even bett

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r on that other side. It can be safe to open your heart and love again. You cannot truly love again until you have let go. Not only can it be safe, bu

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

t it can be more rewarding than you can even imagine. It is a risk to open your hear again, but the rewards are well worth it. Letting go is hard to do

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Summary - Letting Go is Hard to Do: Reflections on Relationships

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