Summary - Relationships

Like gardens, in order to bloom and produce, relationships require upkeep. Basic garden requirements are soil and water. Basic relationship requirements are time and attention. Many couples know these basic requirements and exercise them, yet find that their relationship is not

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

what they wanted it to be. They talk, but nothing ever seems to change. They go through the empty motions of loving each other, but something is missing. The phrase “I love you, but I am not in love with you!” may have been thought or expressed. They wonder, “What am I missing

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

” or “What am I doing wrong?”. If this situation describes your relationship, read on to find the answer.

The missing attribute is courage. Although one assumes they know what ‘courage’ means, taking a closer look at this attribute yields life changing qualities. Courage is re

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

quired in its many forms. The word itself is from a Latin root, cor referring to the heart. Courage also entails firmness, intrepidity, being without fear or depression of spirit, and being resolute.

In considering the origins of the word itself, the first requirement is that

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

person need to be true to their heart. This entails several aspects. One aspect is that the person needs to be aware of what is in their hearts. In contemporary culture, many people are so used to superficial relationships, they are unawares of what is in their hearts. Becomin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

aware of what is in one’s heart requires effort. Before you can have a heart-to-heart talk with your spouse, one needs to know what is in their own heart first. This requires knowing what you feel, think, and believe.

At the simplest, what one feels are the emotions they expe

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

rience. People often react without giving any consideration as to what they felt associated with their reaction. In terms of emotions, there are at least two in any interaction. There is the emotion of what one initially felt, then there is the emotional reaction they had to th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

initial emotion. Becoming aware of one’s feelings requires the effort of practice. Practice is also what is required in communicating those feelings to others, especially your spouse.

The second attribute of courage is firmness. In relationships this means dependability or co

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nsistency. Your partner needs to be able to count on you. When you say something, they have to be able to believe that you will come through. In many relationships the partners say whatever it takes to get through a crisis and then do not do what they say. A friend once told hi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

partner, “Tell me what you want to hear and I’ll say it”. The sad part is that the partner did believe him. The practice of firmness brings about a sense of security. They know when you make a promise, you mean it.

Firmness is not to be confused with stubbornness or heard-hea

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

edness. Confusing the two will lead to miscommunication and conflict. One of the big differences between firmness and stubbornness is the attitude behind them. In stubbornness, there is a selfish, “I am going to do it come hell or high water” mentality. Whereas firmness is “I a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

m going to honor what I said and not let my partner down, even if it costs me.”

The third quality is intrepidity, which means fearlessness or boldness. This is the attribute of being able to speak your mind without fear. In relationships, it means being able to speak up withou

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

fear of your spouse’s reaction or possible rejection. Marriage is the one relationship that you should be yourself in. This is not a blank check to be brazen or rash in speaking to your partner. Speaking fearlessly still requires you show respect when speaking with your partne

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

r. This kind of boldness takes time to develop to its fullest. Although it would be nice if the relationship began with boldness, they often do not. This quality develops as the relationship matures.

The next quality is that of being without depression. This assumes there is

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ot a medical or psychiatric condition predisposing someone to depression. Assuming there is no such condition or situational circumstance, then this refers to being a source of encouragement to your partner. People do not enjoy being around someone who is negative or down all t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e time. When you are with your partner, try your best to be in good spirits and maintain a positive outlook. King Solomon wrote that in order to have friends a man must show himself friendly. This passage speaks to the practice of being a source of encouragement.

The final att

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ribute of courage needed in relationships is resoluteness. This term refers to having a fixed purpose and determination. A simpler way to express this is commitment. In a relationship, your partner needs to know that you are committed to the relationship. When they know that yo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

are committed, and will not be leaving at the first disagreement or crisis, there is a sense of emotional security. In many modern relationships, people often separate when a crisis arises. It is as if in their vows, the promise was made, ‘until crisis causes us to part’. In s

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ituations where crisis will lead to a breakdown of the relationship, people often begin keeping secrets to keep it intact. The relationship becomes tenuous, basing its stability on the parties emotional status rather than on the commitment they made to each other.

Practicing c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

urage in a relationship will transform both the kind of intimacy occurring and the quality of the intimacy. If you are looking for what is needed to bring the relationship from loving each other to being in love with each other, courage is important in making that change happen

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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