Summary - Relationships

I consider myself to be extremely lucky for having apart from two caring and loving parents, also a brother-who entered my life three and a half years after I was b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

orn-to turn to whether I am happy or in distress. Being the oldest child in our family, I was usually the one that had to listen to all the parenting advice before

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

y brother was old enough to take a stand. Although our relationship has been through a lot of ups and downs, now that we both technically belong to the adult group

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

f the family, I consider my brother to be one of the most caring and smart individuals I know and consider him to be irreplaceable in my life.

I catch myself often

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

traveling back in time and remembering with nostalgia those instances that we felt compelled to fight over a toy or a T-shirt, although we both knew that trouble wa

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

on its way since we were supposed to wash our hands and get ready to sit down at the dinner table with our parents. I smile when I recall those Sunday mornings tha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t I had to run to my brother's bedroom as my mother entered his room in order to begin narrating his favorite story. Although I do not remember how this became a fa

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ily "ritual" that lasted throughout our childhood-since the usual practice for kids is to listen to fairytales before getting to bed-my mother was always ready to r

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

peat the story of the righteous young man and his successful fight against the misunderstood monster that frightened the inhabitants of an imaginary village. The to

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e of her voice and the moral of the story always made us wake up with a feeling of excitement that everything in life is possible. Well, I am proud to admit that my

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

brother is a living proof of that old saying. Without hesitating and by being confident of his abilities and his willingness to experience the world, he was the one

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

that took first the step of traveling abroad, studying the subject matter of his choice, becoming a young promising professional in his field of expertise, buying

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

house, and still keep his friends close and my parents happy with his life's choices.

The truth is that our relationship has changed considerably over the years.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hile at the beginning was more or less similar to any brother-sister relationship you have been probably exposed to, although we were not jealous of each other, som

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

how we managed through similar experiences and common life goals to establish a very sincere and open channel of communication. Maybe it seems too honest at times f

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

r me to handle with confidence, but the fact remains that I am grateful to have the opportunity of speaking with my brother whenever I please, to give him my advice

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

when he asks for it and not to be afraid to raise an argument that might not find him in agreement.

Having an adult brother-sister relationship is one of those th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ngs in life I cherish and consider myself extremely lucky for being able to enjoy. My sincere wish for both of us is to continue opening up each other, understand a

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d respect our differences, learn from each others mistakes, and of course, increase the frequency of our visits to one another. One thing I miss terribly is his fac

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

. He is one of the people I know I can laugh with and cry in front of without later feeling embarrassed I did. I consider this feeling to be unique; at least for me

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Summary - An Adult Brother Sister Relationship

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